Blue Zone Methylene Blue

Methylene blue is known to repair cellular metabolic function and is the antidote for cyanide poisoning. Methylene blue (MB) is used intravenously in hospital emergency rooms as the essential remedy for chemical exposures, overdose and any metabolic poison

Methylene blue is shown to quickly inactivate Herpes, West Nile, Hepatitis C, Ebola, Zika, HIV, Dengue, Venoms and COVID (March 2020 published study – MB can “effectively eliminate SARS-CoV-2 in vitro within 2 minutes”.

MB is the first effective anti-malarial drug ever produced and quickly inactivates parasites, bacteria, fungi and viruses. It protects the brain, nervous and cardiovascular system. Our nervous system is under great duress with the electromagnetic bombardment we are currently being exposed to. Protecting our brain and nervous system has never been more important.

Methylene Blue can even prevent a cytokine storm and has antihistamine properties. It has a long history of use for urinary tract infections. MB has been shown to lift depression, and is known to be effective for bipolar disorder and psychosis.

As a sidenote, hydroxychloroquine is derived from methylene blue.

Current scientific research shows that all known diseases are characterized by widespread metabolic dysfunction. A lack of health will be accompanied by an array of symptoms. Regardless of the symptoms, I invite you to consider that there really is only one disease and the path to recovery is to focus on repairing metabolic function within cells. It is truly astounding how effectively MB targets and begins repair of cellular respiration, the metabolic function of the cell.

“The world is catching on to the fact that all diseases are metabolic in nature, and that methylene blue selectively targets cells and tissues that have dysfunctional metabolism.” The Ultimate Guide To Methylene Blue – Mark Sloan

Methylene Blue is a beautiful compound used as a nootropic to increase memory, mood and longevity. MB is an organic chloride salt. It is known as the magic bullet due to its uncanny ability to target diseased tissue and concentrate in the brain; proving effective for Alzheimer’s, dementia, depression and any brain dysfunction. It increases cerebral blood flow and acts as an antidepressant.

Unlike other nootropics that work by increasing neurotransmitter synthesis and neural signalling, methlyene blue improves memory by dramatic increase in brain cell respiration; how the brain cells utilize oxygen. MB also increases cellular glucose uptake – providing more brain & cellular power.

A single dose of Methylene Blue has been shown to improve memory!

As the metabolic rate of the brain declines with age, so too does your ability to think, remember and speak clearly. A groundbreaking study in 2017, reports that as the brain ages, mitochondrial metabolism decreases and that this phenomenon is possibly the main culprit behind many neurological diseases, including Alzheimer’s and Parkinson’s.

Western research into the therapeutic value of methylene blue goes back to the late 1800’s. But it’s only in the last couple of decades that scientists have been able to decode exactly how MB works in the brain. All the way down to the molecular level in mitochondria.

Perhaps one of the most revolutionary benefits of MB is for the prevention and treatment of dementia, neurodegenerative diseases such as Alzheimer’s and Parkinson’s, and neural injuries caused by stroke and traumatic brain injuries (TBIs). This is particularly important as the COVID jabs have radically increased strokes.

As explained by Dr Gonzalez-Lima:

“Any process where increasing oxygen-based energy production plays a major role, methylene blue will have a role to play. One of the first studies we did that was very impressive [was on] a model in the eye. The reason we used the eye was because the retina in animals is readily accessible so that we can inject into the retina.

Rotenone (a broad-spectrum pesticide and Complex 1 inhibitor) inhibits mitochondrial respiration; subsequently there is atrophy and degeneration of the retinal layer, which is very dramatic. If methylene blue is on board, we can prevent this process because the mitochondrial respiration can continue, so the tissue is not affected.

This was a model called an optic neuropathy due to mitochondrial defects. It’s the most common form of blindness in younger people, so we did this to verify in vivo that [methylene blue] could have this neuroprotective effect. Then we did it in other things like brains. We found a similar phenomenon …

Methylene blue can be protective in ischemic and hemorrhagic strokes. We’ve also published a study with a hypoxia. In other words, we reduced the amount of oxygen delivered to the animals, and we could use an fMRI, noninvasively, in the animals to see that we were able to increase the amount of cerebral metabolic rate for oxygen consumption in the presence of methylene blue under hypoxic conditions.

With respect to dementia, by the time you see the tau protein inside neurons, those neurons are metabolically, essentially, dead, so it is too late. By acting on that, you cannot recover the metabolic machinery and the health of the neurons.

So, those neurons are not rescued in any way that is functionally meaningful. Generally speaking, biomarkers are not good therapeutic targets because they may or may not have any causal relationship with the disease.” Dr. Gonzalez-Lima

MB is currently being studied as potential therapy for mild cognitive impairment, Alzheimer’s and Parkinson’s disease, and other neurodegenerative disorders. All these diseases share a common problem with mitochondrial function.

MB assists brain cell respiration by increasing oxygen and donating electrons to the electron transport chain within mitochondria. This same process is used to feed mitochondrial ATP when you eat. So MB provides this fuel without you having to eat. 

https://journals.lww.com/anesthesia-analgesia/fulltext/2007/08000/methylene_blue_administration_is_associated_with.74.aspx

Neuroprotectant: MB is a potent antioxidant. Reactive oxygen species are produced inside mitochondria. The first free radical that is formed inside a cell is superoxide. MB will bind to superoxide and reduce it to water. It stops the oxidative cascade at its very beginning. https://pubmed.ncbi.nlm.nih.gov/24479842/

MB quickly crosses the blood-brain barrier. It improves mitochondrial efficiency and respiration, acts as an antioxidant, and increases brain cell lifespan. Resulting in improved memory and mood. https://pubmed.ncbi.nlm.nih.gov/28738167/

MB boosts neuron resistance to the formation of amyloid plaques and neurofibrillary tangles. And helps repair impairments in mitochondrial function and cellular metabolism. https://pubmed.ncbi.nlm.nih.gov/30003902/

In 2019 scientists gave Alzheimer’s patients MB daily while monitoring their brain function. They witnessed the MB treatment stop the disease. “Treatment with 8-16mg MB daily reduced cognitive decline by 85% over 65 weeks. This is a revolutionary discovery.

Neurons LOVE Methylene Blue!

Methylene Blue is one of the most powerful mitochondrial optimizers on the planet, boosting energy levels, enhancing memory, improving focus, protecting the brain and organs and so much more.

• Cyanide Poisoning
• Carbon monoxide
• Sodium nitrite/nitrate
• Formaldehyde
• Pharmaceutical drugs & Anaesthetics
• Snake Venom
• Antidote for Chemical Poisoning & Overdose
• Heavy metals
• Fluoride, found in toothpaste & tap water
• Potent Antioxidant & Antidepressant
• Antimicrobial (virus, fungus, bacteria, parasites)
• Protects brain, nervous & cardiovascular system
• Repairs cellular metabolism

Methylene blue is a highly effective agent against urinary tract infections (UTIs). Most people dealing with UTI are put on antibiotics, which disrupts their microbiome and confounds the issue. MB was used for many decades to address UTI’s at a dose of 65 mg per day and was even sold in pharmacies as Urolene Blue.

Since your body doesn’t really metabolize MB, it is excreted by your kidneys into your bladder where it reaches very high concentrations over time and becomes a potent oxidant stress that kills virtually any pathogen in the bladder. Plus, it has the additional “side effect” of improving brain health and reducing dementia. In my mind, it is reprehensible medical malpractice not to use MB in UTI’s. It clearly is the safest and most effective drug of choice.

Genetic mutation occurs inside cells, known as hypoxia or insufficient oxygen. MB accelerates cellular oxygen consumption by 70% and restores respiration on the cellular level. Every cell needs to “breathe”; absorb oxygen and expel waste. When a cell can no longer do this, it will become diseased. MB is adaptive to what the body requires for repair, it both receives and donates electrons to accommodate repair.

Methylene blue also activates the Nrf2 pathway. Nrf2 is a transcription factor that, when activated, goes into the cell’s nucleus and binds to the antioxidant response element (AREs) in the DNA. It then induces the transcription of further cytoprotective enzymes such as glutathione, superoxide dismutase catalase, glutathione peroxidase, phase II enzymes, heme-1 oxygenase and many others.

Longer life and better health are associated with mitochondrial function and number. Methylene blue repairs function, increases oxygen and the number of mitochondria within our cells. It is shown to be 1000’s of times more potent than all other known mitochondrial protectors. As MB increases oxygen in the blood and cells, this improves the electrical properties, as well as the metabolic properties. Healthy mitochondria create healthy cellular metabolism and this is the key to a happy long life.

ATP is produced within mitochondria as a final product of respiration, a series of biochemical reactions that extract energy from glucose. These biochemical reactions require oxygen & electron carriers (e.g. NADH). Methylene blue acts as an artificial electron carrier that repairs mitochondrial respiration. The outcome is more energy available as ATP – the energy currency of the cell.

More than 95% of the oxygen that we breathe is used by our mitochondria. The mitochondria inside your cells use that oxygen to produce energy (ATP). Understanding this is the key to understanding life on our planet!

Dr Ana Marla Mihalcea president of AM Medical LLC reports that in some cases a single dose of MB can provide dramatic pain relief for various types of pain. These effects are accumulative with response increasing over time of continued use.

Dr Mihalcea Reports:

• Cases of instant pain relief with Iv methylene blue infusion for osteoarthritis
• Complete pain relief lasting from 8 hours to 1 week
• Significant improvement in quality of life and mood
• Improved pain relief with combination of Iv infusion and oral methylene blue
• Oral or bi-weekly injections of MB improved back and joint pain up to 80% & showed continued improvement over time.
• Reduction of opiate use by 75% of baseline 4 weeks after starting treatment. Some days not needing any pain    medication with continued improvement reported.

Methylene Blue has been in use since 1877 with no major adverse effects ever observed.

Most patients with Progeria die before the reach maturity because of the disease’s increased rate of aging in the body. Hair loss, thin & wrinkled skin, brittle bones & joints are all signs of the condition, even in children. Scientists from the Maryland University discovered that MB can save cells damaged by Progeria.

MB is able to reverse the effects of aging on both the mitochondria and the nucleolus of the cell.

Research shows that methylene blue is an effective anti-aging nootropic. MB increases mitochondrial complex IV by 30%, enhances cellular oxygen consumption by 37-70%, increases heme synthesis, and reverses premature senescence caused by H2O2 or cadmium. https://pubmed.ncbi.nlm.nih.gov/28396091/

“It’s only a matter of time before methylene blue is recognized as one of the most potent medicines ever discovered!” – Mark Sloan

American Journal of Psychiatry reported testing for the elimination of fear and the contextual memory of fear. MB has an amazing effect on synergy between left & right hemispheres of the brain; you become more imaginative and more rational. It demonstrates an uncanny ability to rewire the brain to forget negative associations of a situation while retaining the positive aspects of that memory; this is known as “extinction memory enhancement”. MB provides more focus and contentment with a great ability to help eliminate fear and stress.

Dr Gonzalez-Lima gives the following example of how MB has been used in the treatment of fears and phobias:

“One of the processes in which a memory formation can be used therapeutically is when you form a memory to extinguish fear. Individuals who have a phobia, you can expose them to the specific situation that is involved in the phobia, and there is a learning called extinction learning that happens that you extinguish your response.

In that situation, we only give methylene blue once after this extinction learning to facilitate the process of memory consolidation. What happens after you go through the learning is the process of consolidation, which requires energy.

So, by facilitating the energy availability during the consolidation phase, which happens over a number of hours, then the next time [you’re exposed to fear-evoking stimuli, you’ve] consolidated that extinction memory more effectively.

We’ve done this also with post-traumatic stress disorder (PTSD), where you use prolonged exposure therapy. In that situation, you can give the methylene blue after different sessions where you see that there is a good extinction learning.

In other words, where people are learning through exposure to reduce their fear levels, that’s when you want to reinforce that therapeutic learning by giving them the methylene blue right after the session.”

Indigo or Indigofera tinctoria is the plant from which methylene blue was discovered. It has historical use in Ayurvedic medicine for the treatment of fever, liver and spleen disorders, rheumatoid arthritis, gout, ringworm, blisters, removing worms in teeth and gums, sores on skin, liver, urinary problems, antidote for poisons, mouth ulcers or canker sores, kidney disease rabies and more.

Due to its safety and deep blue colour it is also used extensively in gram staining and clothing dye. Gram staining is one of the most important staining methods in microbiology to determine cell mortality. When applied to a sample, a healthy cell will turn the stain colourless because the cell’s enzymes reduce the MB, causing it to lose its colour. If the cell is dead, there will be no reaction, as the cell’s enzymes have been inactivated.

Methemoglobinemia is a blood disorder seen in poisonings and overdoses of all kinds. Oxidized hemoglobin is unable to carry oxygen, so the ailment causes widespread hypoxia, which can be deadly if not treated quickly. The key to treating this condition is to restore the hemoglobin back to its original (non-oxidized) state. MB is one of the safest and most effective ways to quickly restore hemoglobins ability to carry oxygen.

MB converts ferric iron into ferrous iron. Ferrous iron carries oxygen into the blood.

Doctors administer MB intravenously to methemoglobinemia patients because it is fast, safe and effective for restoring oxygen to the blood. MB acts as an antidote by converting methemo­globin back to hemoglobin, which restores its oxygen-carrying capacity. Once oxygen use is restored, health is restored.

Consider that all chemical poisonings induce methemoglobinemia, which is a condition MB has been FDA approved to treat. When we know how MB can correct the oxygenation of the blood – the root cause of the problem, its value as an antidote for all chemical poisonings becomes obvious.

Most doctors and nurses administering MB for chemical poisonings and overdoses are not aware that MB’s value as an antidote extends far beyond it oxygenating the blood. It is anti-inflammatory, prevents blood clots, prevents and reverses septicemic shock, prevents and can reverse lung fibrosis (when nebulised).

MB works by correcting the defective cellular metabolism caused by the poison.

As an electron cycler, methylene blue acts like a battery, but unlike other compounds that do the same thing, it doesn’t cause damaging oxidation in the process. If anything interferes with oxygenation or cellular respiration, such as cyanide, methylene blue is able to bypass that point of interference through electron cycling, thus allowing mitochondrial respiration, oxygen consumption and energy production to function as it normally would.

The most important complex, Cytochrome c Oxidase, which catalyzes the reaction of oxygen becoming water, is blocked by cyanide. MB can actually insert electrons wherever there is a blockage and restore function.

MB can also be helpful in instances where you have impaired blood flow that prevents the delivery of oxygenated hemoglobin to the tissues. In this case, methylene blue helps counteract the reduced blood flow by optimizing the efficiency of mitochondrial respiration.

In biohacker circles, low-dose methylene blue is used as a nootropic, meaning a compound that helps improve cognitive function. However, while some promote sublingual or buccal application (under your tongue or on the inside of your cheek), the best way is to swallow it, as the acid in your stomach makes it more bioavailable.

There is no true recommended dose for Methylene Blue. It proves a hormetic dose-response, meaning a low dose is effective while a high dose produces opposite results and is counterproductive.

Our recommendation is to start with a low dose and see how you react.

For an acute treatment, the upper limit is between 3 mg to 4 mg per kg, which is typically the range given as an IV antidote for methemoglobinemia. For nonacute, more long-term treatment, 0.5 mg to 1 mg per kg per day works better. It has a half-life of 12 to 13 hours, so once-a-day dosing is fine.

Personally we find one dose in the morning completely adequate. MB is water-soluble so you don’t need to take it with a meal, or healthy fat like some nootropics. Simply add the drops to water or juice.

Suggested Daily Use:

Shake before each use.

Add drops to water or juice

1 drop for every 4kg of body weight

Loading Protocol:

Shake before each use.

Add drops to water or juice

1 drop for every 2kg of body weight for 2 weeks then drop to daily maintenance

When your urine turns a beautiful ocean blue, you have entered the BluZone!

Most people today don’t know that if you overdose on a pharmaceutical or street drug, swallow some toothpaste containing the insidious poison fluoride, or eat a poison mushroom, methylene blue is the first line of treatment doctors and nurses will administer in an emergency. In fact, methylene blue is an effective antidote for virtually all chemical poisonings.

In hospitals, methemoglobinemia patients are administered a MB dose of 2mg/kg intravenously over the course of 5 minutes.

MB is a mild monoamine oxidase (MAO) inhibitor, so taking high doses with a selective serotonin reuptake inhibitor (SSRI) antidepressant could potentially lead to serotonin syndrome, which is not good. The risk of this, however, is very small.

Gonzalez-Lima explains: “With respect to the warning about the SSRIs, the problem is not methylene blue but the amount of SSRI. The problem was in a specific application of methylene blue where they use it for parathyroid surgery as a stain.

To my knowledge, there’s never been more than five cases, where the patients were anesthetized, and they still had SSRIs [in their system], and they did repeated flushing in the open neck with methylene blue, which exceeded these doses that we have been talking about.

The U.S. FDA reacted with this warning. But this has been reviewed by both surgeons and pharmacologists at the Mayo Clinic, and they wrote a rebuttal paper where they indicate that there is no evidence to suggest oral methylene blue has any interaction with the therapeutic dosing of serotonergic compounds, especially SSRIs, and that this was something that happened under these specific [surgical] conditions.

Canada limits the warning to that particular application, but our FDA went beyond that to any kind of serotonergic drug. I think there is absolutely no evidence for oral methylene blue having interactions in this low-dose range with any SSRIs.

And when they talk about the MAO inhibitor function, it really only works as an MAO inhibitor in the higher concentration of the higher dose range, not the low-dose range. So, the effects of methylene blue as an antidepressant — only to a very limited extent, if you repeat it cumulative treatments — can be due to any kind of a MAO inhibitor role.

In addition, it is due to its metabolic enhancing function, so it antagonizes some of the depression symptoms like the low energy that is experienced with depression. So yes, it is effective to reduce symptoms of depression. Unfortunately, this warning is going to make some physicians scared of using it in combination with SSRIs.”